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Present data [59] showed that these two molecules were all upregulated in ARPE-19 cells under oxidative stress

However, overexpression of PGC-1 reduces autophagy marker levels, improves mitochondrial metabolic function and antioxidant capacity, thereby alleviating muscle atrophy, offering a potential approach to age-related sarcopenia (80)

Further studies have found that IPF ECM inhibited miR-29 expression upstream at the transcriptional level, and suppressed Dicer1 downstream at the processing steps to maintain the fibrosis progression (Herrera et al., 2018)

Dynamically tunable light responsive silk-elastin-like proteins