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Keywords: Methylsulfonylmethane, Biological functions, Mechanism of action, Animal production INTRODUCTION With the increasing emphasis on animal health and livestock product safety, the development of non-toxic, residue-free, and multifunctional green feed additives has become an inevitable trend in the development of the livestock industry [1]

Dimou and Simons, 2017

A striking synergistic induction of necrosis was observed in L1210 cells upon combination treatment with PRIMA-1 and the cyclin-dependent kinase inhibitor flavopiridol

Such compounds are able to inhibit SystemX c , thus leading to exhaustion of cysteine in cells, GPX4 inactivation, accumulated lipid peroxides, and eventually ferroptotic cell death

Food Chem Toxicol 86:4155 Ghezzi P (2005) Regulation of protein function by glutathionylation