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Finlay, D

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Signal duration is also impacted by negative feedback regulation of the IRS proteins through serine phosphorylation [32], which disrupts their interactions with upstream receptors and/or downstream effectors, or targets them for degradation via ubiquitin-mediated proteasomal degradation [33,34,35]
Frontiers in nutrition, 12, 1729164

Grape seed-derived procyanidins decrease dipeptidyl-peptidase 4 activity and expression
