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Suppression of NFS1 alone does not induce ferroptosis, but when cells produce large amounts of ROS, iron starvation induced by inhibition of NFS1 promotes ferroptosis

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It is initiated by extracellular stimuli, such as interactions between death receptors and their ligands, or by intracellular signals, including pathogen-derived nucleic acids ( 2.2.1 Classical pathways of necroptosis in SA-AKI Recent research has elucidated that the canonical pathway of necroptosis involves the RIPK1/RIPK3/MLKL signaling axis

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