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For patients with Long COVID and ME/CFS, who are often trapped in a state of chronic, systemic hyper-inflammation, this ability to downregulate pro-inflammatory cytokine cascades while simultaneously supporting targeted antiviral defenses makes L-Lysine a highly valuable therapeutic agent

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In vitro evaluations have revealed that 300 g/mL of trigonelline can trigger its maximum inhibitory effect, reducing the production of TMAO by 85.3% (87)
PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1-Xbp1s pathway expedites liver injury
