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FIGURE 1 Glutathione peroxidase 4 inactivation or depletion induces ferroptosis Glutathione peroxidase 4 (GPX4) scavenges lipid peroxides to generate lipid alcohols, which inhibits Fe 2+ induced reactive oxygen species (ROS) production (Shyu et al., 2014
Acta inhibiendo la enzima NNMT (nicotinamida-N-metiltransferasa), que regula los niveles de NAD+ y participa en el almacenamiento de grasa y el equilibrio energtico
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Xiong L, Xiong Z, Hua J, Chen Q, Wang D
This secondary loop influences the amplitude and phase of clock gene expression
