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In the chronic obstructive pulmonary disease, pro-inflammatory macrophages recruited to the lung upon cigarette smoke exposure were found to increase ACLS4 expression in alveolar typeII epithelial cells leading to increased lipideperoxidation and cell death resulting in emphysema [508]

Oxidative modification of NK surface receptors NKG2D and NKp46 reduces their ability to recognise and bind infected target cells

doi: 10.1159/000495404

As to the age factor, because most of the samples are from elder PD patients, the module conservation analysis has not been performed to check the influence of age

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