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Compromise of tight junction structures between the intestinal lumen and the submucosa may allow immune cells in the subepithelial compartment to produce osteoclastogenic cytokines, which can subsequently enter systemic circulation and disrupt bone homeostasis (52)

Y.LuoW.HeP

Pauta, M
Moreover, silencing Smad4 decreases HIF-1 significantly when combined with hypoxia (Mingyuan et al ., 2018)

The cellular and molecular changes triggered by ROS, as previously discussed, disrupt melanocyte homeostasis and contribute to pathological conditions 111
