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Wnt signaling in stem cell regulation and tissue regeneration In contrast to the Wnt/Frizzled/-catenin axis, which is evolutionarily conserved from early multicellular animals and onward, the R-spondin/Lgr gene families are primarily a vertebrate specific evolutionary addition

2.1% and 1.1%, respectively) and the abundance of MuSCs and progenitors peaked at day 5 (9.7%

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