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This may partly be responsible for the difference in the outcome of DiY cross-linking from the different studies

Experts say, The goal of initial therapy is to correct the deficiency and replenish body stores. The goal of initial therapy is to correct the deficiency and replenish body stores. Clinical Guidelines on Vitamin B12 Deficiency Proper Injection Techniques and Sites Administering Vitamin B12 injections intramuscularly needs proper technique for safety and effectiveness

However, the therapeutic effect of DM, especially on its complications, is not satisfactory

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Copper is a cofactor for tyrosinase and is involved in the conversion of inactive T4 to the biologically active T3, necessary for the synthesis of TPO, a precursor to thyroid hormones, and the subsequent coupling of iodotyrosine residues to form T4 and T3 [6,89]