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Oxidative stress or other stress stimuli induce the dissociation of the Nrf2-Keap1 complex, resulting in Nrf2 nuclear translocation and subsequent binding to the antioxidant response element (ARE) in the regulatory region of the target genes

At present, the precise alterations in insulin signaling and GLUT4 trafficking that underlie insulin resistance (IR) remain incompletely defined

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Statements Author contributions JS, RS, EH, and HG conceived and designed the study, revised the manuscript, and read and approved the submitted version

Laboratory compounds should be discontinued immediately if serious reactions occur