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Acta Haematol 143(6):1-7, 2020

RET fusions as primary oncogenic drivers and secondary acquired resistance to EGFR tyrosine kinase inhibitors in patients with non-small-cell lung cancer

Lewis DF, Lake BG, Bird MG, Loizou GD, Dickins M, Goldfarb PS
Requires proper cycling, monitoring, and understanding of all peptides

The physiology of vitamin B-12 is a multistep process that is characterized by multiple trafficking events, associations and dissociations among several binding/carrier proteins, specific and multiligand receptor-mediated endocytosis, intracellular trafficking into different cellular compartments, and protein-specific controlled exit (1, 2)
