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In summary, advancing the field of human neuroprotection demands a multidimensional recalibration, spanning conceptual clarity, more representative preclinical models, validated biomarkers, and refined clinical endpoints

It plays a central role in cellular detoxification, the neutralisation of reactive oxygen species, and the regeneration of other antioxidants including Vitamins C and E

Indeed, posttranslational modification of IGFBP3 (e.g., glycosylation, phosphorylation) is an essential determinant of IGF-1s ability to bind the IGF-1R
