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Timelines vary based on individual factors and treatment goals

Individual non-responder: Small percentage of individuals don't respond to specific interventions regardless of quality or dosing

[47] However clinical studies using HDACi are currently ongoing and the results are pending, with the Phase II studies showing promise for safe and tolerable use of several compounds such as phenylbutyrate

They found that BMSCs and TSG-6 reduced MMP-3 and MMP-13 expression in IL-1-treated NPCs, thus restoring the expression of type II collagen and proteoglycan

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