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Generation of human metabolites of 7-ethoxycoumarin by bacterial cytochrome P450 BM3

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This central disinhibition and facilitation are further compounded by neuroendocrine dysfunction (e.g., alterations in HPA axis function) and altered signaling of neurotrophins like brainderived neurotrophic factor (BDNF), which can promote synaptic plasticity and hyperexcitability

PMID: 35739195 Eur J Pharm Sci Repurposing of FDA-approved drugs by targeting SIRT2 to alleviate inflammatory response and kidney injury