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Moreover, it acts as a nitrogen donor in purine and pyrimidine synthesis as well as a precursor for protein and glutathione biosynthesis [23]

Recent research has shown that CAFs, a significant group of stromal cells in the TME that emit HGF, trigger the HGF/c-MET pathway and its subsequent signals, thereby facilitating tumor movement and advancement

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[DOI] [PubMed] [Google Scholar] 41.Huang T., Zhang K., Sun L., Xue X., Zhang C., Shu Z., Mu N., Gu J., Zhang W., Wang Y., et al

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