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Several common amine modifiers (aminohexyl, PAMBA) and backbones (PS, PO and PNA) are readily accepted at different positions within the oligonucleotide, and full conversion with nearly no degradation is seen in short reaction times (30 min)

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Once in circulation, NAD+ is distributed to tissues across the body

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Snyder PJ, Bhasin S, Cunningham GR, et al

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