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This latter finding is consistent with reports that uptake and metabolism of acetate occurs primarily in astrocytes [123, 127], in contrast to ALCAR which is metabolized in both neurons and astrocytes [57]

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HTML is then cleaved by HTML aldolase (HTMLA, a pyridoxal phosphate requiring enzyme), yielding 4-trimethylaminobutyraldehyde (TMABA) and glycine

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The aim of this review is to provide a comprehensive overview of the multidimensional biological effects of the carnitine pool beyond FAO, and to explore its potential applications and impacts on intercellular communication, inter-organ metabolic interactions, and overall metabolic health