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The subcutaneous route may be unreliable in patient with conditions that result in impaired blood flow, such as circulatory shock (Dougherty and Lister, 2015)

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In patients with mild, moderate and severe renal impairment, mean desmopressin exposure was 1.5 fold, 2.4 fold and 3.6 fold higher, respectively compared to that of subjects with normal renal function [see Contraindications (4), Use in Specific Populations (8.6)]