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doi: 10.1016/j.intimp.2016.10.008

Differentiation of monocytes to mature tissue macrophages is generally associated with a reduction of their microbicidal activity, partly due to a substantial decrease in oxygen-dependent mechanisms of toxicity leading to a much lower level of respiratory burst and MPO function [167,168,169,170]

L.HoklandP.PedersenL.AutrupH.2002Effect of glutathione S-transferases on the survival of patients with acute myeloid leukaemia.4381-2, (March 2002),1518,0014-2999 5

The pancreatic secretion of intrinsic factor is reduced or absent, secondary dysbiosis of the intestine is common, and the mucosa may be compromised by the presence of excessive bacterial numbers and toxic metabolites

[2] Signs and symptoms [edit] A reaction typically begins within 24 hours of exposure and peaks at 4872 hours after exposure