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In hepatic stellate cells, transforming growth factor-1 (TGF-1) markedly upregulated -SMA expression, a key marker of fibrosis, through activation of the MAPK signaling pathway

Exosomemediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer

Targeting microglial metabolic rewiring synergizes with immune-checkpoint blockade therapy for glioblastoma

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Thiopurines in the Treatment of Steroid-Refractory Ulcerative Colitis In the case of steroid resistance, i.e., a lack of clinical improvement during induction therapy, or steroid dependencea clinical remission during steroid therapy, but a flare during dose reduction or within 3 months of discontinuing treatmentnext-line medications are used