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An example of this is denosumab, which binds the trimeric target RANKL, but forms drug to target complexes at a limited ratio of 3:2 ( While the aim of this study was not to prove the mechanism of AMG 966 immunogenicity, understanding the nature of immunogenicity from clinical data is important for further engineering of such biologics
MCLACHLAN, M.S.F., CHICK, S., ROBERTS, E.E., & ASSCHER, A.W
Potential Side Effects and When to Seek Medical Advice B12 injections are generally well-tolerated, with serious adverse effects being rare

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