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Consequently, this results in a reduction in the expression of PGC-1 (Pirooznia et al., 2020)

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Furthermore, iron deficiency disrupts mitochondrial function and its essential role in oxidative metabolism, ATP production (via the tricarboxylic acid cycle), and related enzymatic activities, leading to dysregulated cellular metabolism

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Metabolic surgery has also been found to alter production of gut hormones and may cause changes in the gut microbiome, thereby affecting signaling pathways related to appetite, glycemic control, and inflammation (Xu 2021