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We further examined the mechanisms behind the therapeutic effect of Fer-1 by extracting brain tissues from HSV-1-infected mice treated with 10 mg/kg Fer-1 at 2, 4, and 5 dpi (Fig

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Common quality-control elements include: Chromatographic purity by HPLC or an equivalent validated chromatographic method Identity confirmation by mass spectrometry Where available, net peptide content or quantitative assay information Analytical method validation principles for identity, purity, specificity, accuracy, precision, and related parameters are addressed in ICH Q2(R2), while FDA guidance on analytical procedures and method validation emphasizes that analytical procedures should be suitable for their intended purpose