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Generally, canonical Wnt cascades such as Wnt3a can stimulate insulin secretion and enhance the proliferation of cell by activating -catenin/TCF/LEF-mediated Cyclin D1 transcription

However, it should be pointed out that the progress of TI research is still in its infancy and faces important challenges

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Pathogenesis of obesity White adipose tissue primarily consists of fat-storing cells known as adipocytes, which store energy from food as triglycerides