ibuprofen glutathione depletion chris kresser The Dangers of Proton Pump Inhibitors Vitamins and Minerals in CKD
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Tang J, Yin C, Chen M, Dong M, Xu Y
But there are reasons why the B12 in your body may dip below normal

Additionally, enzymes such as xanthine oxidase and nitric oxide synthase are activated, generating ROS that react with nitric oxide (NO) to form peroxynitrite, further aggravating oxidative stress
Chen Q, Tao J, Xie X

10.1038/s41419-021-04389-x 239 ZhangB.PengH.ZhouM.BaoL.WangC.CaiF.et al (2022a)