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Obesity and T2DM are both characterized by insulin resistance (IR), proinflammatory cytokines, mitochondrial dysfunction, endoplasmic reticulum stress as well as dysfunctional fatty acid metabolism [22]

Y1230C and Y1235D mutations consistently promote HNSCC metastasis

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Another study in adult rats showed that peripheral infusion of IGF-1 increased progenitor cell proliferation and selectively induced hippocampal neurogenesis [27]