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Administration of oral GSH increased hepatic GSH levels in: (i) rats fasted 48 hours, (ii) mice treated with GSH depletors, and (iii) mice treated with paracetamol (a drug which promotes a depletion of hepatic GSH followed by hepatic centrilobular necrosis)

1000 mg/day, P.O for 12 weeks) in patients with CHD [189, 190]

[DOI] [PubMed] [Google Scholar] 213.Sargeant TD, Aparicio C, Goldberger JE, Cui H, Stupp SI

It decreases the efficacy of the chemotherapy by causing patient discomfort and often resulting in dosage reduction or chemotherapy treatment termination

For several decades, it was established that the levels of many antioxidant enzymes, including catalase, decline with age [89]