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Endothelial cells produce various molecules in response to injury, including interleukin-8, interferons, chemokines, colony-stimulating factors, monocyte chemoattractant protein-1, intercellular adhesion molecule-1, E-selectin, growth factors, P-selectin, vascular adhesion molecule-1, and other inflammatory factors [8]

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is associated with higher levels of circulating BCAAs, which are known risk factors for insulin resistance ( In mouse models of PCOS, abnormal bile acid profiles are closely associated with the pathophysiology of the disease (Wang et al., 2026)

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This induction in BALB/c was entirely dependent on IL-4RA, IgE- and FCER1A-expressing cells and could be partially prevented by pretreating mice with zileuton (ALOX5 inhibitor), montelukast (CysLTR1 inhibitor) or HAMI3379 (CysLTR2 inhibitor) before each challenge (Fig