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Among these, SGLT2 inhibitors stand out as the most successful example, having advanced from mechanistic insights to multiple large-scale RCTs and guideline-recommended first-line therapy
These effects contribute to restoring the normal functioning of inflamed tissues
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ONC201, a dual inhibitor of Akt and ERK, is being evaluated in combination with paclitaxel for the treatment of platinum-resistant ovarian cancer in an ongoing phase II trial (NCT04055649)
