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Moreover, myofibroblast activation and the development of multiple organ fibrosis are substantially attenuated in CD38-null mice with elevated NAD + 24

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Toxicity from B12-derived cyanide has never been documented even with mega-dose supplementation

We thus hypothesized that CD38 upregulation might have a fundamental pathogenic role in SSc fibrosis, and further, restoring NAD + homeostasis will prevent the process