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An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R

[DOI] [PMC free article] [PubMed] [Google Scholar] 144.Amirshahrokhi K., Bohlooli S

Cobalamin (vitamin B 12 ) Deficiency Investigation & Management Early treatment of cobalamin deficiency is particularly important because neurologic symptoms may be irreversible

The metabolic shift toward glycolysis in M1 macrophages is further regulated by sterol regulatory element-binding protein 1 (SREBP1), which ensures a continuous supply of substrates for fatty acid synthesis to sustain the heightened metabolic demands of inflammation ( Our revision highlights the distinct roles of SFAs, MUFAs, and PUFAs in shaping macrophage behavior and function

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