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A 12 week uncontrolled, open-label phase II pilot study
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Nanotechnology-based drug delivery systems loaded with different drugs in various combinations offer a solution to these problems by enhancing the pharmacokinetics of the drugs, and allowing accumulation of drugs in the tumor tissue, and sustaining synergistic effect of rate constants of the drugs to facilitate uptake by the cells [53]
RNAseq library preparation To generate BT474 persister cells for RNAseq, BT474 cells were plated in five 15 cm tissue culture plates per replicate, for three replicates, and were allowed to reach 75% confluency before being treated with 2 M lapatinib for nine days
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