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However, the membrane-proximal S2 subunit contains more extensive N-glycan shielding 132,133 and is less accessible for immune recognition than the S1 subunit and is therefore less immunogenic

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This suggests potential alterations in L-tryptophan flux towards production of tryptamine and DMT rather the 5-HT in ASD (see Fig

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doi: 10.2337/db13-0639 202

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