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Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone

In addition to supporting biosynthesis, NADPH produced in the oxPPP can be either antioxidant or pro-oxidant

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Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect

The binding of these antibodies to postsynaptic receptors, subsequently, complement activation and membrane attack complex formation, results in reduced expression of AchR