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15-PGDH degradation leads to PGE2 accumulation and excretion to the tumor microenvironment, resulting in aggravating inflammation [46, 47]
[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Verdin E NAD + in aging, metabolism, and neurodegeneration
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Research also documents upregulation of growth hormone receptor expression and signaling pathways related to cell growth, proliferation, survival, and angiogenesis
