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Internally responsive nanosystems Internally responsive nanosystems are activated by sensing and responding to the intrinsic characteristics of the TME, such as weak acidity, high ROS levels, overexpressed enzymes, or metabolites

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Studies suggest that bendamustine can achieve comparable CAR T cells expansion but may reduce adverse effects, such as neutropenia, though its use is less common (189)

These strains contribute to maintaining the integrity of the gut lining, which is essential for overall health and performance in athletes (Smarkusz, Ostrowska, and WitczakSawczuk 2017

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