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Blood 128 , 702 (2016)

doi: 10.1016/j.bbrc.2009.04.149

For instance, heme can cause surface epithelial cells to remain susceptible to cytotoxic damage that alters surface-to-crypt signaling, leading to hyperproliferation and ultimately hyperplasia of crypt cells in mice supplied heme (Wolff and Nourooz-Zadeh, 1996)

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