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Melatonin can reduce oxidative stress and stimulate the synthesis of antioxidant enzymes (SOD, GPX, and glutathione reductase) and GSH production (Plascencia-Villa and Perry, 2021)

Glutathione Redox Potential and NADPH: Theoretical Considerations and Potential Importance in Signaling A key outstanding issue is to what extent GR activity ensures that the glutathione and NADP(H) couples are in thermodynamic equilibrium (at the same redox potential)

doi: 10.1016/0006-2952(66)90197-3

One possible exception is the slight decrease in serine coupled due to increase in glycine

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