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In addition, as an epigenetic modification, DNA methylation can be involved in disease progression and serve as a marker of environmental exposures, such as tobacco smoking, lipid peroxidation, and inflammation ( GSTA4 promoter, which contains antioxidant response elements, may act as an adaptive mechanism through which they are transcriptionally activated during exposure to lipid peroxidation of the vascular wall in IA patients ( GSTA4 methylation may serve as a biomarker of vascular impairment in patients with IA

Glutathione and its precursors (such as cysteine peptides) are absorbed intestinally and distributed systemically [66], reaching dermal tissues to exert photoprotective and skin-lightening effects, particularly relevant for women concerned with age-related pigmentation changes [74, 75]

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Lattivazione di questo recettore innesca una catena di reazioni allinterno della cellula