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4.3 Sorafenib Sorafenib has been shown to have inhibitory effects against platelet-derived growth factor receptor (PDGFR), VEGFR2, VEGFR-3, PDGFR- and other receptors (135)

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But the clinical evidence base is thinner than the marketing suggests, and critical questions about skin penetration, optimal formulation, and long-term outcomes remain unanswered
Behavioral approaches can also address habits and triggers without adding a new substance
While animal studies suggest safety, long-term human studies are lacking