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LL-37 stimulates the generation of ROS through NADPH oxidase activation and intracellular calcium mobilization, so inhibition of LL-37 by AzA reduces ROS generation [23]

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Mitochondria contain multiple copies of their own genome, mitochondrial DNA (mtDNA), which encodes for 13 polypeptides of the OXPHOS and respiratory chain, as well as two ribosomal RNAs and 22 transfer RNAs necessary for translation of polypeptides inside mitochondria

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