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Additionally, in vitro cultures of mouse embryonic stem cells (ESCs) treated with lactate have shown the promotion of H3K18la modification in the promoter regions of genes related to germline and cleavage stage embryos, facilitating their widespread expression [39]

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In animal studies, researchers have observed inflammatory changes in mouse brain tissue, including activation of microglia, loss of dopaminergic neurons and aggregation of -syn in the substantia nigra