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doi: 10.1016/j.immuni.2024.12.012 143 BoyleRJShamjiMH

Melanin accumulation in dermal stem cells deteriorates their exosome-mediated skin basement membrane construction in solar lentigo

However, chemotherapy fails in nearly 90% of cases because tumor cells develop resistance against the anticancer agent, resulting in increased cancer invasion the progression to metastases, which increases the difficulty of treating cancer effectively (2)

Nevertheless, this technique possesses limitations as it can only be applied to specific categories of macromolecules with an electric charge [9]

25 The combination of high levels of inflammatory signals, increased comorbid conditions, and reduced function of the immune system increases the vulnerability of aged individuals to infection