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In contrast, rest alone is not a cure for CRF in fact, excessive rest may worsen conditioning and fatigue

Alternatively, multiple lines of evidence suggest that mitochondrial dysfunction may play a role in psychiatric disorders [182], Moreover, there is a high comorbidity rate between mitochondrial diseases and mental disorders [183,184]

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Eur Rev Med Pharmacol Sci 25:6773 [DOI] [PubMed] [Google Scholar] 94.Nelson T, Zhang LX, Guo H, Nacul L, Song X (2021) Brainstem abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome: a scoping review and evaluation of magnetic resonance imaging findings