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This trans-cellular transport generates a 4-fold plasma-to-CSF ascorbate gradient in rats [45,52], resulting in CSF concentrations of about 200-400 M [53,54], compared to plasma concentrations of 60 M or less (Fig

These engineered T cells depend on various metabolic pathways to support their activation, proliferation, and effector functions, which are closely associated with the limited efficacy of CAR-T cells in solid tumors

This panel also includes vitamin D, HbA1c and Insulin