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2019;5(9) doi: 10.1126/sciadv.aaw2778

Rousselle C, Clair P, Lefauconnier J-M, Kaczorek M, Scherrmann J-M, Temsamani J

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Interestingly, inhibition of JAK/STAT signaling by ruxolitinib suppressed C/EBP transcriptional activity, leading to a reduction in systemic inflammation by SASP repression and improvement in fitness in elderly mice (94)

This is the safest point to begin to assess tolerance and minimize the risk of side effects
