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Although some therapeutic benefits appear to exhibit more statistical significance than clinical meaning, the seemingly tiny improvement in these trials is capable of being replicated

In addition, the effect of low-dose naltrexone (4.5 mg/day) on daily self-reported pain and overall life satisfaction, positive mood, sleep quality and fatigue was investigated in a small cohort of patients [89]

Supplements are typically divided into groups, depending on the levels of evidence they have
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PLoS ONE 4(5): e5268
