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Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated mean body weight reductions of up to approximately 24% over 48 weeks in adults with obesity a notable finding, though long-term durability data and head-to-head comparisons with other treatments are not yet available

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Klassische Schlafmittel haben charakteristische Probleme: Benzodiazepine entwickeln Toleranz und Abhngigkeit, Z-Drugs (Zolpidem, Zopiclon) verursachen Hangover und kognitive Beeintrchtigungen, sedierende Antihistaminika reduzieren Tiefschlaf paradoxerweise

DiamondS.et al.2010Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications, 24