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3.1.12 Silymarin Silymarin, a lipophilic extract from the seeds of Silybum marianum, is protective against ototoxicity by inhibiting the expression of caspase-3 and PARP in cisplatin-induced cleavage through mechanisms such as scavenging of free radicals, reduction of ROS formation, and inhibition of fatty acid peroxidation (Cho et al., 2014b)

Another emerging target is ceramide synthase 6 (CerS6), a key regulator of sphingolipid metabolism implicated in sterile inflammation

E.GerstnerA.HarthR.DirrA.JanetzkyB.KuhnW.RiedererP.GerlachM

[DOI] [PMC free article] [PubMed] [Google Scholar] Okumura R., Koizumi Y., Sekiya J

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